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At the conclusion of the first scenario, the patient is unsure if shehas a disease, unclear how she might have gotten one, and uncertain how to prevent some-thing similar from happening again. As withsimple vulvectomy, sitz baths should be avoided, and the vulvar area should be kept cleanand dry. El-Hizawi S, Lagowski JP, Kulesz-Martin M, Albor A (2002) Induction of gene ampli? cationas a gain-of-function phenotype of mutant p53 proteins

El-Hizawi S, Lagowski JP, Kulesz-Martin M, Albor A (2002) Induction of gene ampli? cationas a gain-of-function phenotype of mutant p53 proteins. Tests that determine (or estimate) theeffects of an agent on fertility, gestation, and offspring;usually conducted on more than one generation of testanimals. They do this by regulatingtotal body salt (e.g., sodium, potassium, and chloride ions),water, and acid–base balance (e.g., proton, bicarbonate, andammonia transport and metabolism), reabsorbing nutrients(e.g., glucose, amino acids), and excreting waste products(e.g., urea, creatinine, uric acid, phosphates, sulfates)

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The patient outcomes, which in a Phase I study are not particularlyimproved by the experimental treatment, were morbid.

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